靶点背景信息

***-gamma (IFN-gamma ) is a secreted protein which belongs to the type II *** family. IFN-gamma is produced by a variety of immune cells under inflammatory conditi***, notably by T cells and NK cells. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functi***. ***-gamma is a central regulator of the immune resp***e and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway.

文献引用

Periostin deficiency reduces PD-1+ tumor-associated macrophage infiltration and enhances anti-PD-1 efficacy in colorectal cancer

PMID:

36773295